Table 1.
Table 1 Comparisons of adult bipolar-I disorder patients with onset in childhood, adolescence or adulthood
| Onset age group | |||||
| Child (<12) | Adolescent (12-18) | Adult (19-55) | χ² or F | p | |
| Cases (n) | 53 | 335 | 980 | - | - |
| % women | 34.0 | 53.1 | 57.4 | 11.6 | 0.003 |
| Onset age (years) | |||||
| Mean ± SD | 7.94±2.03 | 16.9±1.78 | 30.2±10.2 | - | <0.0001 |
| Median (IQR) | 8.00 (4.00) | 16.0 (2.00) | 28.0 (13.1) | - | - |
| Current age (years, mean ± SD) | 34.1±9.83 | 38.4±11.1 | 45.7±12.8 | 59.7 | <0.0001 |
| Years of illness (mean ± SD) | 26.2±9.54 | 22.0±11.4 | 15.5±10.4 | 64.9 | <0.0001 |
| Family affective history (%)* | 88.6 | 66.3 | 61.6 | 11.1 | 0.004 |
| Episodes/year (mean ± SD)* | 1.06±1.71 | 0.68±0.72 | 0.79±0.89 | 3.92 | 0.02 |
| % of months/year ill (mean ± SD) | 46.9±41.1 | 39.7±35.4 | 33.7±32.7 | 2.69 | 0.07 |
| Ever hospitalized (%) | 82.9 | 86.2 | 81.3 | 2.35 | 0.31 |
| Ever psychotic (%)* | 16.2 | 38.9 | 53.5 | 24.8 | <0.0001 |
| Ever attempted suicide (%) | 27.3 | 27.8 | 20.4 | 4.45 | 0.11 |
| Any psychiatric co-morbidity (%)* | 90.9 | 54.1 | 57.4 | 5.71 | 0.06 |
| Education ≥ high school (%) | 53.8 | 61.6 | 63.1 | 1.05 | 0.59 |
| Ever married (%) | 37.0 | 44.7 | 58.4 | 24.2 | <0.0001 |
| With children (%) | 10.0 | 29.2 | 38.1 | 6.52 | 0.04 |
| Employed (%) | 37.5 | 62.0 | 71.8 | 28.2 | <0.0001 |
| Living independently (%) | 0.00 | 43.9 | 75.5 | 16.9 | 0.0002 |
| Functionally impaired (%)* | 60.9 | 42.7 | 30.2 | 31.5 | <0.0001 |
| * Significantly different in patients with onset in childhood versus adolescence | |||||