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. 2012 Jan 24;122(2):693–710. doi: 10.1172/JCI60214

Figure 6. Studies of ischemic AKI in Ent1 bone marrow chimeric mice or in Ent1–/– mice reconstituted with human ENT1.

Figure 6

(A–D) Assessment of GFR, serum creatinine, MPO, and quantification of histologic tissue injury in Ent1 bone marrow chimeric mice (Control: sham-operated wild-type mice transplanted with wild-type bone marrow; KO: Ent1–/– mice; n = 4). (E) Ent1–/– kidneys were injected with saline or with a human ENT1-encoding lentivirus. After 24 hours, transcript levels of Ent1 were determined by real-time RT-PCR relative to β-actin (n = 4). (F–I) Assessment of renal adenosine, GFR, serum creatinine, and MPO tissue levels following 30 minutes of ischemia and indicated reperfusion times (n = 4).