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. 2012 Jan 17;122(2):575–585. doi: 10.1172/JCI61034

Figure 4. Adaptive immune cells are not required for the tumoricidal effect of Imi.

Figure 4

(A and B) Graphs showing the relative tumor volume of (A) M3 melanomas intradermally induced in Foxn1nu mice (nu/nu mice) and (B) B16-F10 melanomas induced in Rag2–/– and Rag2+/– mice as controls (n = 11–13 per group). (C–E) Relative tumor volume of M3 melanoma–bearing mice depleted of (C) NK cells by injection of anti-NK–specific antibodies (clone Asialo GM1); (D) CD4+ cells by anti-CD4 antibody injection (clone GK1.5); or (E) CD8α+ cells by anti-CD8α antibody injection (clone 53.6.7) before starting treatment with Imi (n = 8–9 per group). Untreated DBA/2 (WT) mice were used as controls. depl., depletion. (F) The percentage of CD8α+ pDCs (CD11b–B220+) gated from CD45+CD11c+ cells present in melanomas of mice depleted of CD8α+ cells 3 days after starting Imi treatment. *P < 0.05, **P < 0.005, ***P < 0.0005.