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. 2012 Jan 24;122(2):497–506. doi: 10.1172/JCI61598

Figure 6. Effects of anti-29b and pre-29b in AngII infusion model and miR-29b regulation in human patients with AAA.

Figure 6

(A) AAD (in percentage versus baseline) in scr-miR and anti- and pre-29b AngII-induced. (B) Col1a1, (C) Col3a1, and (D) Eln expression in scr-miR– and anti- and pre-29b–transduced mice compared with that in sham-operated mice in the AngII model (n = 4–6 mice for each time point and group). (E) miR-29b is the only significantly downregulated miR in human AAA samples (n = 8) compared with tissue from control patients (n = 7) without AAA. (F) COL1A1, COL3A1, COL5A1, and ELN are significantly upregulated in human AAA tissue compared with non-aneurysmal aortic tissue. Data are mean ± SEM. *P < 0.05 versus sham or control patients. #P < 0.05 versus scr-miR and sham. †P < 0.05 versus scr-miR and anti-29.