. Author manuscript; available in PMC: 2012 Jan 26.

Published in final edited form as: J Surg Res. 2010 Apr 1;163(2):214–220. doi: 10.1016/j.jss.2010.03.021

Table 1.

Characteristics of gastroesophageal cancer cell lines.

Cell Name	Type and Derivation	Tum or formation	Mouse model	Adhesion status	Genetic Characterizations

AGS	moderately differentiated adenocarcinoma EBV-	flank tum or	nude mice	low level of E-cadherin expresses LI-cadherin	Expresses Villin 1 LGALS4
OCUM-2MD3	scirrhous poorly differentiated carcinoma derived from OCUM-2M	peritoneal dissemination	nude mice	downregulation of E-cadherin and integrin β4	down regulation of squamous cell differentiation marker gene cluster
BE3	Barrett’s esophagus associated esophageal adenocarcinoma from distal esophagus	flank tum or	nude mice	unknown	Expresses pIκκβ(S¹⁸¹) pTSC1(S⁵¹³) pS6Kl(T³⁸⁹) members of the inflammation associated signaling pathway
MKN-1	adenosquamous carcinoma established from lymph node metastases	flank tum or	nude mice	E-cadherin silenced by promoter hyperm ethylation	missense mutation of p53
MKM-45	poorly differentiated adenocarcinoma diffuse type	peritoneal dissemination	nude SCID mice	wild type allele of E-cedherin lost	CEA + amplification of c-m et proto-oncogene wild type p53 expresses low levels bcl-2
MKN-74	intestinal type moderately differentiated tubular adenocarcinoma derived from liver metastases	peritoneal dissemination	nude SCID mice	no genetic alteration to E-cadherin	CEA − wild typep53 does not express bcl-2