Skip to main content
. Author manuscript; available in PMC: 2013 Feb 1.
Published in final edited form as: Hypertension. 2011 Dec 27;59(2):355–362. doi: 10.1161/HYPERTENSIONAHA.111.180968

Figure 2. Effects of MCT and sildenafil treatments on RV morphometric and RV systolic function.

Figure 2

A–B, RV weight was measured after 24 hours of drying at 37°C (A) and normalized to LV+septum weight (B). N=5, 6, 7, 5 hearts per group, respectively. C–D, RV dimensions during systole (C) and diastole (D), and RV wall thickness during diastole (E). F, RV fractional shortening (FS, %), calculated as (RV dimension during diastole – RV dimension during systole) divided by RV dimension during diastole. N=11, 10, 9, 8 per group, respectively. MCT treated rats developed RVF with significant reduction in RV FS. Sildenafil early treatment prevented MCT induced RVF with maintained FS. Sildenafil late treatment improved RV systolic function, comparing to those of MCT alone. **, p < 0.001 vs. saline control; †, p<0.05; ††, p < 0.001 vs. MCT group; ‡, p<0.05 vs. SilMCT/D1 group.