Table 3.

Odds-ratios and 95% confidence intervals for risk of cutaneous melanoma in relation to type of allele for selected gene variants and naevus category according to subsample, Q-MEGA (1987–2005) (n=2497)

		Controls (n=1469)	All cases (n=1028)		Adults (n=819)		Children (n=36)		Adolescents (n=102)		Men over 50 years (n=69)
		Prop.	Prop.	Adjusted ORa (95% CI)	Prop.	Adjusted ORa (95% CI)	Prop.	Adjusted ORa (95% CI)	Prop.	Adjusted ORa (95% CI)	Prop.	Adjusted ORa (95% CI)	p-valueb
MTAP
rs10757257
G (A)		0.58	0.64	1.32 (1.14–1.53)	0.63	1.32 (1.14–1.54)	0.64	1.27 (0.79–2.05)	0.63	1.22 (0.91–1.63)	0.66	1.41 (0.99–2.02)	0.52
PLA2G6
rs132985
C (T)		0.52	0.56	1.07 (0.93–1.24)	0.56	1.08 (0.93–1.25)	0.61	1.42 (0.87–2.32)	0.52	1.00 (0.75–1.34)	0.54	1.05 (0.74–1.49)	0.23
IRF4
rs12203592
T (C)		0.23	0.20	1.01 (0.83–1.22)	0.21	1.04 (0.85–1.27)	0.10	0.35 (0.16–0.77)	0.16	0.61 (0.42–0.91)	0.22	0.90 (0.59–1.37)	0.0008
Naevus category
None/a few or <10		0.67	0.46	1.00 (Reference)	0.49	1.00 (Reference)	0.19	1.00 (Reference)	0.22	1.00 (Reference)	0.65	1.00 (Reference)
Moderate or 10–50		0.27	0.41	2.39 (1.92–2.98)	0.39	2.23 (1.78–2.80)	0.53	6.55 (2.73–15.73)	0.55	6.34 (3.82–10.55)	0.28	1.06 (0.61–1.83)	<0.0001
Many or >50		0.06	0.13	3.07 (2.14–4.39)	0.12	2.79 (1.92–4.05)	0.28	15.47 (5.70–41.97)	0.23	12.30 (6.60–22.93)	0.07	1.27 (0.49–3.27)	<0.0001
				Ptrend<0.0001		Ptrend<0.0001		Ptrend<0.0001		Ptrend<0.0001		Ptrend=0.68

^aAdjusted for ancestry score, age, number of naevi, freckling, skin colour and hair colour

^bTest for homogeneity in estimates across subsamples

CI: Confidence Interval; OR: Odds-Ratio