Table 5.

Odds-ratios and 95% confidence intervals for subtype-specific risk of cutaneous melanoma in relation to type of allele for selected gene variants and naevus category (n=2497)

		Controls (n=1469)	Cases (n=1028)
			SSM/NM (n=759)			LMM (n=31)			Othera (n=238)
		Prop.	Prop.	Crude OR (95% CI)	Adjusted OR* (95% CI)	Prop.	Crude OR (95% CI)	Adjusted ORb (95% CI)	Prop.	Crude OR (95% CI)	Adjusted ORb (95% CI)	p-valuec
MTAP
rs10757257
G (A)		0.58	0.64	1.30 (1.14–1.48)	1.34 (1.15–1.57)	0.52	0.78 (0.47–1.29)	0.79 (0.46–1.35)	0.64	1.29 (1.06–1.58)	1.33 (1.06–1.66)	0.06
PLA2G6
rs132985
C (T)		0.48	0.45	1.14 (1.01–1.30)	1.06 (0.91–1.23)	0.47	1.04 (0.63–1.74)	1.00 (0.58–1.71)	0.43	1.21 (0.99–1.47)	1.12 (0.90–1.40)	0.84
IRF4
rs12203592
T (C)		0.23	0.19	0.80 (0.68–0.93)	0.94 (0.76–1.15)	0.26	1.16 (0.66–2.05)	0.99 (0.50–1.98)	0.22	0.93 (0.74–1.17)	1.27 (0.95–1.70)	0.87
Naevus category
None/a few or <10		0.67	0.47	1.00 (Reference)	1.00 (Reference)	0.64	1.00 (Reference)	1.00 (Reference)	0.42	1.00 (Reference)	1.00 (Reference)	-
Moderate or 10–50		0.27	0.41	2.17 (1.80–2.63)	2.40 (1.90–3.03)	0.33	1.26 (0.58–2.72)	2.20 (0.97–4.99)	0.39	2.34 (1.73–3.18)	2.38 (1.70–3.35)	0.84
Many or >50		0.06	0.12	2.96 (2.15–4.07)	2.74 (1.88–4.01)	0.03	0.58 (0.08–4.34)	0.92 (0.12–7.33)	0.19	5.18 (3.42–7.85)	4.24 (2.64–6.82)	0.31
				Ptrend<0.0001	Ptrend<0.0001		Ptrend=0.98	Ptrend=0.24		Ptrend<0.0001	Ptrend<0.0001

^aIn the total population of invasive cases (n=1028), the 238 melanomas from this category included 234 melanomas not otherwise specified, 2 amelanotic melanomas, and 2 desmoplastic melanomas

^bAdjusted for ancestry score, sex, age, number of naevi, freckling, skin colour and hair colour

^cTest for homogeneity in estimates between SSM/NM and LMM