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. Author manuscript; available in PMC: 2012 Jan 26.
Published in final edited form as: Nature. 2011 Jul 10;475(7356):353–358. doi: 10.1038/nature10238

Figure 2. NavAb pore module.

Figure 2

a, Pore-lining S6 helices of NavAb (yellow) and the closed MlotiK (3BEH), KcsA (1K4C) and NaK (2AHY) channels. Cα locations of Met221 defines a common radius for the closed activation gate (red circle). b, Comparison of S6 helices of NavAb and KV1.2/2.1 (2R9R). c, Interaction of S6 with S4-S5 linkers (NavAb, top; KV1.2/2.1, bottom). d, Architecture of the NavAb pore. Glu177 side-chains (purple sticks); pore volume, grey. e, Electrostatic potential colored from −10 to 10 kT (red to blue).