Table 1. Association of common HLA haplotypes with IgAD.

		Sweden/Iceland (430 Cases, 1090 Controls)				Spain (256 Cases, 322 Controls)				Finland (86 Cases, 564 Controls)
HLA haplotype	N (%)	Freq Cases	Freq Controls	P value	OR	Freq Cases	Freq Controls	P value	OR	Freq Cases	Freq Controls	P value	OR	Combined P value	Combined OR (95% CI)
DRB1*0301	907	0.295	0.136	2.87×10−21	2.54	0.205	0.120	7.37×10−5	1.96	0.273	0.114	1.75×10−7	2.78	1.56×10−34	2.49 (2.14–2.90)
B*0801-DRB1*0301-DQB1*02	634 (69.9%)	0.254	0.097	9.79×10−24	2.96	0.106	0.026	2.26×10−7	4.50	0.233	0.083	1.80×10−8	3.57	3.37×10−43	3.33 (2.79–3.97)
Recombinant DRB1*0301 (non-B*0801)	273 (30.1%)	0.042	0.039	0.712	1.08	0.100	0.093	0.708	1.08	0.041	0.03	0.455	1.38	0.424	1.10 (0.84–1.44)
DRB1*0701	625	0.145	0.081	1.91×10−7	1.93	0.277	0.165	6.76×10−6	1.94	0.134	0.046	3.66×10−5	2.94	8.68×10−17	2.03 (1.70–2.41)
B*1302-DRB1*0701-DQB1*02	90 (14.4%)	0.017	0.008	0.037	2.06	0.023	0.009	0.061	2.59	0.076	0.023	3.13×10−4	3.69	1.36×10−5	2.63 (1.69–4.09)
Recombinant DRB1*0701-DQB1*02 (non-B*1302)	463 (74.1%)	0.109	0.049	3.42×10−9	2.44	0.229	0.132	3.57×10−5	1.92	0.105	0.038	3.13×10−4	2.92	6.35×10−17	2.23 (1.83–2.72)
Recombinant DRB1*0701 (non-DQB1*02)	162 (25.9%)	0.036	0.033	0.629	1.11	0.049	0.033	0.165	1.52	0.029	0.008	0.019	3.81	0.027	1.34 (0.96–1.86)
DRB1*0102	140	0.027	0.003	6.42×10−7	8.74	0.141	0.045	3.36×10−8	3.69	0.023	0.004	0.013	5.45	5.86×10−17	4.28 (2.92–6.26)
B*1402-DRB1*0102-DQB1*05	93 (66.4%)	0.023	0.002	2.72×10−6	13.24	0.086	0.030	6.77×10−5	3.11	0.023	0.002	2.74×10−3	13.71	1.24×10−16	4.59 (2.89–7.30)
Recombinant DRB1*0102 (non-B*1402)	47 (33.6%)	0.003	0.001	0.254	2.55	0.055	0.016	3.88×10−4	3.83	0	0.003	0.498	N/A	3.62×10−3	3.22 (1.70–6.13)
DRB1*0101-DQB1*05	786	0.123	0.121	0.848	1.02	0.102	0.107	0.762	0.94	0.337	0.211	4.20×10−4	1.86	0.038	1.17 (0.98–1.39)
DRB1*1501	574	0.027	0.151	9.82×10−17	0.16	0.008	0.107	5.08×10−7	0.07	0.017	0.13	2.65×10−4	0.12	2.24×10−35	0.13 (0.09–0.19)
B*0702-DRB1*1501-DQB1*06	280 (48.8%)	0.015	0.077	5.90×10−9	0.18	0.002	0.034	5.65×10−3	0.06	0	0.067	4.51×10−4	N/A	8.23×10−17	0.14 (0.08–0.24)
Recombinant DRB1*15 (non-B*0702)	294 (51.2%)	0.012	0.073	1.28×10−8	0.15	0.006	0.073	1.77×10−5	0.08	0.017	0.063	0.021	0.25	3.70×10−18	0.14 (0.09–0.24)

Shown are the summary statistics describing the association of select haplotypes on the 3 independent European case-control series. Recombinant haplotypes were defined as segments of the respective extended haplotypes and result from the occurrence of a recombination event between the HLA-B and HLA-DRB1 genes. Combined P values and odds ratios were calculated as described in Methods. N, number of haplotypes; Freq, frequency; OR, odds ratio; N/A, not available. Extended haplotypes and individual recombination events are depicted in Figure 2.