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. Author manuscript; available in PMC: 2012 Feb 1.
Published in final edited form as: Psychopharmacology (Berl). 2011 Aug 11;219(4):1055–1063. doi: 10.1007/s00213-011-2433-y

Fig. 1.

Fig. 1

Genetic deletion or pharmacological blockade of CRF-R1 does not alter acute MA sensitivity. a Locomotor activity counts (mean+ SEM) from male and female CRF-R1 KO and WT mice following administration of saline on days 1–2, and 2 mg/kg MA on day 3 (n=5–10 per sex, per genotype). b Acute MA stimulation scores (day 3 activity minus day 2 activity; mean+SEM) from male and female CRF-R1 KO and WT mice. c Locomotor activity counts (mean+SEM) from male B6 mice following administration of vehicle followed by saline on days 1–2, and either vehicle or 10 mg/kg CP-376,395 (CP) followed by either saline or 2 mg/kg MA on day 3 (n=8 per group). d Acute MA stimulation scores (day 3 activity minus day 2 activity; mean+SEM) from male B6 mice