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. Author manuscript; available in PMC: 2012 Dec 28.
Published in final edited form as: Oncogene. 2011 Oct 17;31(26):3164–3176. doi: 10.1038/onc.2011.480

Figure 2. NF-κB activation in IKTA transgenic mice enhances lung tumorigenesis after urethane injection.

Figure 2

A) Timeline for treatment of mice with a single IP injection of carcinogen (urethane, 1 g/kg) and doxycycline (dox) during three different time intervals. B) WT and IKTA mice were treated with dox for 2 weeks prior to urethane and continued for another 3 weeks (week -2–3). WT mice without dox were used an additional control (n=9–11 per group, *=p<0.01 compared to the other groups). C) WT and IKTA mice were treated with dox beginning at 4 weeks after urethane and continued until the time of harvest (week 4–16) (n=14 for WT and 7 for IKTA, *=p<0.01 compared to WT). D) WT and IKTA mice treated with dox beginning 2 weeks before urethane and continuing for the duration of the experiment (week -2–16). A group of IKTA mice without dox treatment (IKTA) was included (n=7–9 per group, *=p<0.01 compared to the other groups).