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. Author manuscript; available in PMC: 2012 Dec 28.
Published in final edited form as: Oncogene. 2011 Oct 17;31(26):3164–3176. doi: 10.1038/onc.2011.480

Figure 7. Tregs in the lungs of IKTA transgenic mice exhibit immunosuppressive properties and enhance lung carcinogenesis.

Figure 7

A) CD4+CD25+ T cells from lungs of dox-treated IKTA mice impair the ability of allogeneic dendritic cells (DC) to induce proliferation of CFSE-labeled responder CD4+CD25- T cells (Teff). B) Flow cytometry assessment of lung-infiltrating T cells (from CD45+CD3+ gate) in IKTA mice at 1 week after a single IP dose of 500 μg of anti-CD25 (PC61) or isotype control antibodies. C) Surface tumors per left lung from mice treated with anti-CD25 antibodies (CD25) or isotype control antibodies (IgG) the day prior to urethane treatment and on day 6, followed by repeated IP injections every 2 weeks for 4 months (n=5–7 per group, *=p≤0.05 for IKTA mice treated with anti-CD25 Ab compared to IKTA mice treated with isotype control Ab).