Table 1.
Population characteristics and CAD events by classification of ischemia severity (N = 1,287)
| Characteristics | None (n = 1129) | Minimal (n = 76) | Mild (n = 64) | Moderate or severe (n = 18) |
P value |
|---|---|---|---|---|---|
| Age, years† | 46.1 ± 7.0 | 47.8 ± 7.3 | 50.0 ± 5.9 | 47.5 ± 8.0 | <.0001 |
| Male sex (%) | 40.8 | 80.3 | 76.6 | 83.3 | <.0001 |
| African American (%) | 48.0 | 38.2 | 37.5 | 44.4 | .16 |
| Hypertensive (%) | 47.7 | 56.6 | 60.9 | 77.8 | .007 |
| Diabetic (%) | 9.2 | 10.5 | 7.8 | 27.8 | .06 |
| Current smoking (%) | 31.3 | 39.5 | 29.7 | 38.9 | .43 |
| Low-density lipoprotein cholesterol, mmol/L (mg/dL)† |
3.68 ± 1.14 (142.1 ± 44.0) | 4.07 ± 1.09 (157.0 ± 42.2) | 4.2 ± 1.29 (163.0 ± 49.8) | 4.11 ± 1.13 (158.7 ± 43.5) | .0001 |
| High-density lipoprotein cholesterol, mmol/L (mg/dL)† |
1.36 ± 0.42 (52.4 ± 16.3) | 1.25 ± 0.34 (48.1 ± 13.2) | 1.21 ± 0.38 (46.8 ± 14.8) | 1.19 ± 0.33 (45.8 ± 12.9) | .003 |
| Triglycerides, mmol/L (mg/dL)† |
1.58 ± 1.33 (139.5 ± 118.1) | 1.77 ± 1.10 (157.0 ± 97.2) | 2.02 ± 1.36 (178.6 ± 120.2) | 1.76 ± 1.00 (156.1 ± 88.4) | .04 |
| Body-mass index (kg/m2)† |
29.3 ± 6.4 | 28.9 ± 5.1 | 29.1 ± 4.6 | 29.9 ± 4.7 | .91 |
| MET level achieved | 11.1 ± 3.2 | 11.2 ± 3.1 | 11.2 ± 3.0 | 11.1 ± 3.3 | .99 |
| Incident CAD event rates Incident ACS event (%)‡ |
8.4 | 19.7 | 25 | 38.9 | <.0001 |
P value across categories of ischemia severity as measured by 17-segment semi-quantitative analysis [none (0%), minimal (1% to 5%), mild (5% to 10%), moderate (10% to 15%), and severe (≥15%)].
†
Mean ± 1 standard deviation.
‡
Acute coronary syndromes (ACS) defined as sudden cardiac death, acute myocardial infarction, or unstable angina requiring revascularization.