Table 1.
Compounds | Binding (Ki ± SEM) data of phenyl piperazine analogs at selected receptors (nM) | |||||||
---|---|---|---|---|---|---|---|---|
# | X | Y | D2 | D3 | D4 | 5HT1A | 5HT2A | 5HT2C |
Cloza | 130 | 240 | 54 | 140 | 8.9 | 17 | ||
Hal, 1a | C=O | COH | 0.89 | 4.6 | 10 | 3600 | 120 | 4700 |
5 | CH2 | COH | 24 ± 2 | 666 ± 39 | 1.5 ± 0.1 | 658 ± 50 | 302 ± 23 | MP |
6 | S | COH | 8.8 ± 9.5 | 49.0 ± 1.7 | 247.8 ± 4.3 | 317 ± 29 | 72 ± 7 | >10000 |
7 | O | COH | 5.3 ± 0.3 | 182 ± 22 | 2.4 ± 0.1 | 74.0 ± 6 | 93 ± 10 | MP |
8 | S | CH | 185 ± 13 | 130 ± 14 | 39 ± 3 | 454 ± 92 | 112 ± 17 | >10000 |
9 | O | CH | 41 ± 4 | 696 ± 50 | 9.5 ± 0.3 | 169 ± 15 | 121 ± 9 | >10000 |
10 | S=O | CH | 998 ± 68 | 243 ± 35 | 35 ± 1 | 613 ± 216 | 222 ± 17 | >10000 |