Table 2.
Compounds | Binding (Ki ± SEM) data of phenyl piperazine analogs at selected receptors (nM) | ||||||||
---|---|---|---|---|---|---|---|---|---|
# | A | X | Z | D2 | D3 | *D4 | 5HT1A | 5HT2A | 5HT2C |
11a | F | C=O | 4-Cl | 254 ± 39 | 404 ± 66 | 17.5 ± 2.0 | 90.9 ± 21.0 | 110 ± 16 | 3552 ± 943 |
12 | F | CH2 | 4-Cl | 284 ± 21 | 261 ± 23 | 7.8 | 112 ± 7 | 81 ± 5 | MP |
13 | F | S | 4-Cl | 211 ± 22 | 422 ± 41 | 8.7 | 166 ± 12 | 53 ± 3 | MP |
14 | F | S | 4-CF3 | 4753 ± 593 | 544 ± 58 | 89 | 1080 ± 389 | 1129 ± 114 | MP |
15 | F | O | 4-Cl | 390 ± 34 | 885 ± 65 | 6.9 | 80 ± 6 | 60 ± 4 | MP |
16 | F | O | H | 37 * | 207* | 7.4 | 24.0* | 57.6 ± 2.8 | MP |
17 | H | O | 4-Cl | 447 * | 726* | 5.6 | 154* | 19.8 ± 1.0 | MP |
18 | H | O | H | 119 * | 79.3 ± 13.7 | 4.5 | 25.0* | 46.0 ± 4.2 | MP |