. Author manuscript; available in PMC: 2013 Feb 1.

Published in final edited form as: Bioorg Med Chem. 2011 Dec 22;20(3):1291–1297. doi: 10.1016/j.bmc.2011.12.019

Table 2.

Binding of Phenyl Piperazine Analogs at at Dopamine and Serotonin Receptors of Interest.


Compounds			Binding (Ki ± SEM) data of phenyl piperazine analogs at selected receptors (nM)
#	A	X	Z	D₂	D₃	^*D₄	5HT_1A	5HT_2A	5HT_2C
11^a	F	C=O	4-Cl	254 ± 39	404 ± 66	17.5 ± 2.0	90.9 ± 21.0	110 ± 16	3552 ± 943
12	F	CH₂	4-Cl	284 ± 21	261 ± 23	7.8	112 ± 7	81 ± 5	MP
13	F	S	4-Cl	211 ± 22	422 ± 41	8.7	166 ± 12	53 ± 3	MP
14	F	S	4-CF₃	4753 ± 593	544 ± 58	89	1080 ± 389	1129 ± 114	MP
15	F	O	4-Cl	390 ± 34	885 ± 65	6.9	80 ± 6	60 ± 4	MP
16	F	O	H	37 ^*	207^*	7.4	24.0^*	57.6 ± 2.8	MP
17	H	O	4-Cl	447 ^*	726^*	5.6	154^*	19.8 ± 1.0	MP
18	H	O	H	119 ^*	79.3 ± 13.7	4.5	25.0^*	46.0 ± 4.2	MP

The synthesis and DA binding data of compound 11 were previously reported in Ref 9 and 10; MP = Missed primary assay threshold of 50% inhibition.

The SEM of the binding data of compounds with asterisk are less than 20%