. Author manuscript; available in PMC: 2013 Feb 1.

Published in final edited form as: Bioorg Med Chem. 2011 Dec 22;20(3):1291–1297. doi: 10.1016/j.bmc.2011.12.019

Table 3.

Binding Data for Aryl Piperazine Analogs at Dopamine and Serotonin Receptors of Interest.


Compounds			Binding (Ki ± SEM) data of aryl piperazine analogs at selected receptors (nM)
Compd #	X	Ar	D₂	D₃	D₄	5HT_1A	5HT_2A	5HT_2C
19	C=O	2-Pyrimidine	98.0 ± 15.0	244.1 ± 106.0	6.5 ± 0.8	30.5 ± 5	22.0 ± 4.0	4132 ± 1081
20	CH₂	2-Pyrimidine	269 ± 17	262 ± 17	6.2 ± 0.3	8.6 ± 0.7	41.0 ± 2.0	MP
21	S	2-Pyrimidine	424 ± 25	68.0 ± 10.0	21.0 ± 1.0	93.1 ± 29.0	27.0 ± 2.0	8829 ± 2674
22	O	2-Pyrimidine	636 ± 66	778 ± 63	4.2 ± 0.1	23.0 ± 3.0	23.0 ± 1.0	>10000
23	CH₂	2-Pyridine	124 ± 10	86.0 ± 4.0	3.5 ± 0.2	1.1 ± 0.1	50.0 ± 3.0	MP
24	S	2-Pyridine	183 ± 21	160 ± 16	5.7 ± 0.3	6.2 ± 0.5	26.0 ± 1.0	8097 ± 495
25	O	2-Pyridine	186 ± 16	229 ± 20	1.8 ± 0.1	3.6 ± 0.2	18.0 ± 1.0	8277 ± 497

MP = Missed primary assay threshold of 50% inhibition,