Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Design of bivalent ligands. (A) Monovalent ligands for the MetJ dimer. (B) Design of symmetrical bivalent SAM analogues; the optimal separation of the terminal carbon atoms in the linker was expected to be ∼5.3 Å. (C) Illustration of the possible interaction between an exemplar bivalent ligand and the MetJ homodimer. In this example, a simple linker joins the terminal carboxyls of two binding units analogues via secondary amides.
