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| Histological features to be evaluated |
|---|
| Diffuse architecture (greater than one third of the tumor) |
| Clear cells comprising 25% or less of the tumor |
| High nuclear grade (grade 3 or 4 according to Fuhrman criteria) |
| Mitotic rate ≥ 6 per 50 high-power fields |
| Atypical mitotic figures |
| Necrosis |
| Venous invasion |
| Sinusoidal invasion |
| Capsular invasion |
The presence of three or more criteria highly correlates with malignant behavior
