Figure 2.

In vivo confocal microscopy grading system of inflammatory features. Images are 400×400 μm. A, Inflammatory infiltrate: seen as multiple bright white nuclei. The mean inflammatory cell density of 3 randomly selected volume scans is calculated. The individual scan with the highest density of cells from within the volume scan is used. B, Dendritiform cells: graded as present or absent. To be present, the mean number of DCs per volume scan needs to be ≥1. The largest number of DCs in any individual scan in a volume scan is used for measurement. A mean number of ≥1 is used to differentiate occasional DCs seen in scans of otherwise normal subjects. C, Tissue edema: seen as multiple black empty spaces. Graded as present or absent (present if seen in any volume scan). D, Papillae: seen as elevations with a central vascular network. Graded as present or absent (present if seen in any volume scan).