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. 2012 Mar 19;367(1590):820–829. doi: 10.1098/rstb.2011.0320

Figure 2.

Figure 2.

Possible evidence for convergent evolution. (a) Nucleotide sequence alignment of exon-2 of the most common alleles of HLA-B*52:01 and B*51:01 groups. The alleles B*52:01:01 and B*52:01:02 differ only by one nucleotide replacement at the third nucleotide of codon 23. The allele B*52:01:02 shares the same nucleotide with B*52:01:02. A putative distinct origin for B*52:01:01 and B*52:01:02 can be postulated; B*52:01:02 may have originated from a gene conversion event in which B*51:01:01 was the recipient of a DNA fragment of a minimal size of 14 nucleotides spanning codons 63–67. The donor of this fragment may be B*40:02:01; many other alleles of HLA-B have identical sequence in the donor segment and could be alternative donor candidates. (b) Distribution of B-C haplotypes bearing the alleles B*52:01:01 and B*52:01:02. Frequency maps for all alleles at all loci are available at http://www.pypop.org/popdata/. Adapted from Solberg et al. [20].