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Structural basis of the effectiveness of measles vaccine. (A) Epitopes of anti-MV-H monoclonal antibodies (red) on the MV-H homodimer (blue white) with potential N-linked sugars (mesh, black) as viewed downwards from the top. (B) Receptor-binding sites on MV-H. Left, crystal structure of MV-H–SLAM (SLAM shown in cyan). Middle, crystal structure of MV-H–CD46 (CD46 in purple). Right, putative nectin-4 binding sites (green), based on site-directed mutagenesis of MV-H.
