Mean Pain Now, Typical, Best and Worst, and RMDQ by group and visit. OMT = osteopathic manipulative treatment; UCO = usual care only. (A) Effect of time (P<0·001) and treatment group (P = 0·025) were significant, but interaction (P = 0·175) was not. (B) Effect of time (P<0·001) and treatment group (P = 0·020) were significant, but interaction (P = 0·473) was not. (C) Effect of time (P<0·001) was significant; however, group effect (P = 0·065) was not. (D) Effect of time (P<0·001) was significant. Group (P = 0·198) and the time x group interaction (P = 0·080) were not significant. (E) Effect of time (P<0·001) was significant; however, the interaction (P = 0·691) and treatment group (P = 0·197) were not.