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. Author manuscript; available in PMC: 2012 Jan 27.
Published in final edited form as: J Nanomed Nanotechnol. 2011 Sep 10;Suppl 4:003. doi: 10.4172/2157-7439.S4-003

Figure 4. Macrophages facilitate transport of nanozyme across the BBB in murine model of PD.

Figure 4

3H-catalase nanozyme loaded into BMM (black diamonds) or cell-free nanoparticles (white squares) were injected i.t.v. in MPTP-intoxicated mice. In parallel experiment, BMM loaded with thye same amount of nanozyme were injected to healthy animals (crosses). Blood and brain samples at various time points were taken, and radioactivity levels were recorded. Results from N=6 mice per group (± SEM) demonstrating significant increase in cell-incorporated nanozyme transport across the BBB compared to cell-free nanoparticles (*) and transport of BMM-incorporated nanozyme in healthy mice (#). Statistical significance is shown by asterisk (p<0.05).