Table I.
Performance of noninvasive tests to diagnose rupture of the fetal membranes.
| Test/Reference | Name of test | Cutoff | Sensitivity (%) | Specificity (%) | PPV (%) | NPV (%) |
|---|---|---|---|---|---|---|
| Nitrazine (pH) | - | Positive/negative | 90-97 | 16-70 | 63-75 | 80-93 |
| Ferning and/or pooling | - | Positive/negative | 51-98 | 70-88 | 84-93 | 87-97 |
| AFP | ROM Check® (Adeza Biomedical Corp., Sunnyvale, CA) | >30/μg/l | 90-94 | 95-100 | 94-100 | 91-94 |
| Fetal fibronectin | - | > 50 ng/ml | 97-98 | 70-97 | 74-93 | 98-100 |
| IGBP-1 | PROM-TEST® (Medix Biochimica, Kauinianen, Finland) AMNI Check® (MAST Diagnostica, Reinfield, Germany) | >3/μg/l | 74-97 | 74-98 | 73-97 | 56-95 |
| Prolactin | - | > 30-50/μIU/ml | 70-95 | 76-78 | 72-84 | 75-93 |
| Diamine oxidase | > 25 /μIU/test | 83 | 90-100 | 100 | 89 | |
| β-hCG | - | > 40-65 /μIU/ml | 68-95 | 70-95 | 73-91 | 78-97 |
| Urea and creatinine | - | >0.12-0.6 mg/dl | 90-100 | 87-100 | 94-100 | 91-100 |
| AmnioSense Absorbent pad | pH > 5.2 | 98.3 | 70 | 65-70 | 98 | |
| Lactate | Lac test® | ≥4.5 mmol/1 | 79-86 | 88-92 | 88-92 | 78-87 |
| PAMG-1 | AmniSure® Test ROM (AmniSure® International LLC, Cambridge, MA) | >5.0 ng/ml | 98-99 | 88-100 | 98-100 | 91-99 |