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Specific activity of the wild-type and mutant enzymes of β4Gal-T1
| Enzyme | UDP-GalNAc → GlcNAc (pmol/min/ng)# | UDP-GlcNAc → GlcNAc (pmol/min/μg)* |
|---|---|---|
| WT-β4Gal-T1 | 0.02 | ND |
| Y289L-β4Gal-T1 | 22 ± 5 | 65 ± 1 |
| R228K-β4Gal-T1 | 0.67 ± 0.04 | ND |
| R228K-Y289L–β4Gal-T1 | 29 ± 6 | 207 ± 8 |
ND, none detected. The GalNAc-T activity is expressed as per nanograms of protein (#) compared with GlcNAc activity (*), which is per micrograms of protein.
