Table 1.

Genes and pathways targeted by recurring mutations in 12 WGS ETP ALL cases.

Gene	N	Case (Mutation)
JAK1	2	003 (S703I), 005 (I631>RGI)
JAK3	3	012 (M511I), 013 (M511I), 007 (A573V)
NRAS	3	008 (Q61H), 012 (Q61P), 001 (Q61H)
KRAS	1	002 (G60D)
BRAF	1	002 (G466E)
FLT3	1	011 (D835Y)
RUNX1	3	006 (R166*), 011 (V124fs), 012 (V164A, translocation involving chrs 8,7,21,10)
PHF6	3	012 (R274Q) 013 (M125I) 005 (exon 8 splice)
ECT2L	2	009 (V588G), 007 (E384D)
EP300	2	006 (L1639P), 007 (exon 10 splice)
GATA3	2	003 (R276Q), 007 (R276Q)
GATA2	1	011 (R307W)
RELN	2	003 (S1719S) 011 (A2114A)
IL7R	2	007 (GCinsL243) 003 (V253>GFSV)
EED	3	001 and 006 (deletion), 004 (S259F)
EZH2	2	009 (deletion) 013 (R684H)
SUZ12	3	006 and 012 (deletion), 013 (S369fs)
HNRNPA1	1	005 (F298fs)
HNRNPR	1	013 (S202fs)