Table 10.
Microarray analyses of RNA after treatment with LPS, LPS + dexamethasone (Dexa), or dexamethasone (Dexa) of macrophages from 8-week-old C57BL/6 male mice.
| Ageing | Genes Up-regulated by LPS | |||||
|---|---|---|---|---|---|---|
| # | Genes | LPS | LPS + Dexa | Dexa | Description | function |
| 1 | IL-6 (IFNβ2) | 341.52 | 100.53 | 1.21 | Interleukin 6 (interferon β2) | NF-κB & IL-6 Signaling |
| 2 | CD40 | 258.44 | 100.54 | 6.03 | CD40 antigen (TNF receptor superfamily) | Signaling |
| 3 | IL-1β | 249.03 | 46.52 | 2.09 | Interleukin-1β | NF-κB & IL-6 Signaling |
| 4 | IFIPT | 186.05 | 90.83 | -6.37 | Interferon Induced protein with tetrarocopeptide | Protein |
| 5 | HD | 152.95 | 8.62 | 3.78 | Histidine decarboxylase | Enzyme |
| 6 | TRAF1 | 150.74 | 73.45 | -1.74 | TNF receptor-associated factor 1 | Signaling |
| 7 | USP9 | 134.50 | 105.70 | 76.70 | Ubiquitin specific protease 9 | Peptidase |
| 8 | IL1RA | 125.10 | 74.86 | 40.46 | Interleukin 1 receptor antagonist | Signaling |
| 9 | CD69 | 105.21 | 37.08 | -1.79 | CD69 Antigen (p60, early T-cell activation) | Antigen |
| 10 | VCAM1 | 95.405 | 31.684 | -3.435 | Vascular cell adhesion molecule | Cell cycle |
| 11 | RASGRP1 | 90.88 | 13.61 | 1.89 | RAS guanyl releasing protein 1 | Inflammation-linked |
| 12 | CCL8 | 87.72 | 5.59 | 1.46 | Chemokine (C-C motif) ligand 8 | Chemokine |
| 13 | SERPIN | 46.27 | 3.35 | -2.34 | Serine or cysteine proteinase inhibitor | Inhibitor |
| 14 | ABCC | 42.89 | -3.86 | 9.67 | ATP-binding cassette, subfamily C | Protein |
| 15 | ICAM1 | 41.21 | 30.85 | -2.12 | Intercellular adhesion molecule 1 | Inflammation-linked |
| 16 | IL1α | 39.92 | 12.01 | -1.90 | Interleukin 1α | NF-κB & IL-6 Signaling |
| 17 | LRRC17 | 31.20 | 24.00 | 9.72 | Leucine rich repeat containing 17 | Inhibitor |
| 18 | IL-12α | 29.59 | 6.65 | 2.16 | Interleukine-Natural killer cell stimulatory factor 1 | NF-κB & IL-6 Signaling |
| 19 | TNFAIP | 25.39 | 26.59 | 5.04 | Tumor necrosis factor, ?-induced protein 3 | Anti-inflammation |
| 20 | NFKBI | 25.15 | 24.08 | 1.94 | Nuclear factor of kappa light polypeptide gene | Transcription regulator |
| 21 | ATP2A2 | 24.00 | 30.09 | 53.82 | ATPase, Ca++ transporting, cardiac muscle | Enzyme |
| 22 | 9230106B05 | 13.48 | 27.43 | 119.10 | RIKEN cDNA 9230106Bo5 gene | Enzyme |
| 23 | UBE2 | 10.41 | 4.56 | 32.53 | Ubiquitin conjugating enzyme E 2A | Enzyme |
| 24 | ABCC | 10.11 | 3.67 | 27.22 | ATP-binding cassette, subfamily C | Protein |
| 25 | PKI | 3.87 | 5.93 | 29.40 | Protein Kinase (cAMP-dependent catalytic inhibi) | Enzyme |
| Ageing | Genes Down-regulated by LPS | |||||
| # | Genes | LPS | LPS + Dexa | Dexamethasone | Description | function |
| 1 | ABCD2 | -43.36 | -2.06 | 4.69 | ATP-binding cassette, subfamily D member 2 | Protein |
| 2 | RASGRP3 | -36.19 | -46.69 | -1.39 | RAS guanyl releasing protein 3 (GRP3) | Protein |
| 3 | PTBP2 | -32.63 | -11.47 | -6.69 | Polypyrimidine tract binding protein 2 | Protein |
| 4 | IFNGR1 | -28.05 | -16.15 | -2.4 | Interferon gamma receptor 1 | Signaling |
| 5 | TNP1 | -24.67 | -13.06 | -2.92 | Transition protein 1 | Protein |
| 6 | 4930503B16 | -22.71 | -6.49 | -2.08 | RIKEN cDNA gene | Enzyme |
| 7 | PHKA2 | -22.65 | -7.54 | 3.32 | Phosphorylase kinase, alpha 2 (liver) | Enzyme |
| 8 | UBE2D2 | -22.6 | -10.76 | -18.83 | Ubiquitin conjugating enzyme E2D2 | Enzyme |
| 9 | HCAP-G | -22.08 | -3.55 | -4.89 | Chromosome condensation protein G | Protein |
| 10 | ATP6V1H | -1.52 | -1.36 | -18.75 | ATPase, H+ trrransporting lysosomal V1 | Transport |
| 11 | LRRN1 | -1.51 | -500 | -12.78 | Leucine rich repeat neuronal 1 | Enzyme |
| 12 | PRKGII | -1.39 | -5.34 | -17.23 | Protein kinase, cGMP-dependent type II | Kinase |