Table 9.
Microarray analyses of RNA after treatment with LPS, LPS + δ-tocotrienol, or δ-tocotrienol of macrophages from C57BL/6 male mice.
| Genes Up-regulated by LPS | ||||||
|---|---|---|---|---|---|---|
| # | Genes | LPS | LPS + δ-Tocotrienol | δ-Tocotrienol | Description | Function |
| 1 | IL-6 (IFNb2) | 341.52 | 184.38 | 8.74 | Interleukin 6 (interferon β2) | NF-κB & IL-6 Signaling |
| 2 | CD40 | 258.44 | 104.31 | 3.75 | CD40 antigen (TNF receptor superfamily mem-5) | Signaling |
| 3 | IL-1β | 249.03 | 126.71 | 1.07 | Interleukin 1β | NF-κB & IL-6 Signaling |
| 4 | IFPIT | 186.05 | 143.32 | -3.77 | Interferon induced protein with tetratrocopeptide | Protein |
| 5 | Tgtp | 78.14 | 40.54 | 1.29 | T cell specific GTPase | Enzume |
| 6 | TRAF1 | 150.74 | 89.04 | 4.06 | TNF receptor associated factor 1 | Signaling |
| 7 | IL-1RA | 125.74 | 175.73 | 57.18 | Interleukin-1 receptor antagonist | Signaling |
| 8 | CD69 | 105.21 | 41.59 | 1.10 | CD69 antigen (P60, early T-cell activation antigen) | Antigen |
| 9 | CCND2 | 101.81 | 43.91 | 5.33 | Cyclin D2 | Cell cycle |
| 10 | VCAM1 | 95.41 | 63.90 | -4.94 | Vascular cell adhesion molecule | Inflammation-linked |
| 11 | RASGRP1 | 90.88 | 47.77 | 3.81 | Ras guanyl releasing protein 1 | Protein |
| 12 | CCL8 | 87.72 | 11.31 | -1.05 | Chemokine (C-C motif) ligand 8 | Chemokine |
| 13 | IL-12β | 70.51 | 34.17 | -1.68 | Interleukin12β | NF-κB & IL-6 Signaling |
| 14 | SOCS3 | 62.94 | 39.81 | -2.92 | Suppressor of cytokine signalling 3 | Anti-inflammation |
| 15 | TNF | 54.11 | 53.41 | -1.98 | Tumor Necrosis factor | NF-κB & IL-6 Signaling |
| 16 | SERPIN | 46.27 | 44.43 | 1.05 | Serine or cysteine proteinase inhibitor | Inhibitor |
| 17 | ABCC | 42.89 | -5.22 | 5.00 | ATP-binding cassette, subfamily C | Protein |
| 18 | ICAM1 | 41.21 | 29.89 | -1.11 | Intercellular adhesion molecule 1 | Inflammation-linked |
| 19 | IL-1α | 39.92 | 32.79 | 1.58 | Interleukin 1α | NF-κB & IL-6 Signaling |
| 20 | ATP2A2 | 24.00 | 48.36 | 57.91 | AtPase, Ca++ transporting cardiac muscle twitch | Enzyme |
| 21 | ACTL6B | 22.49 | 23.29 | 14.23 | Actin-like 6B | Protein |
| Genes Down-regulated by LPS | ||||||
| # | Genes | LPS | LPS + δ-Tocotrienol | δ-Tocotrienol | Description | Function |
| 1 | ABCD2 | -43.36 | -39.75 | -5.51 | ATP-binding cassette, subfamily D member 2 | Protein |
| 2 | RASGRP3 | -36.19 | -19.54 | -1.07 | RAS guanyl releasing protein 3 (GRP3) | Protein |
| 3 | PTBP2 | -32.63 | -2.64 | 2.20 | Polypyrimidine tract binding protein 2 | Protein |
| 4 | IFNGR1 | -28.05 | -4.72 | -3.75 | Interferon gamma receptor 1 | Signaling |
| 5 | TNP1 | -24.67 | -13.88 | -2.87 | Transition protein 1 | Protein |
| 6 | PHKA2 | -22.65 | -6.95 | 2.71 | Phosphorylase kinase, alpha 2 (liver) | Enzyme |
| 7 | UBE2D2 | -22.60 | -17.39 | -7.53 | Ubiquitin conjugating enzyme E2D2 | Enzyme |
| 8 | 4930503B16 | -22.71 | -1.18 | -2.11 | RIKEN cDNA gene | Enzyme |
| 9 | PSMB2 | -1.44 | -1.91 | -25.58 | Proteasome (prosome macropain) subunit, β-type 2 | Peotidase |
| 10 | GIMAP1 | -1.205 | -3.16 | -20.29 | GTPase, IMP family member 1 | Ion Exchange |