Table 2.
ALOX5AP, LTA4H and LTB4R SNPs and COPD susceptibility in smokers.
| SNP | Location | Controls (n = 176) | COPD (n = 599) | Additive | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 0 | 1 | 2 | MAF | 0 | 1 | 2 | MAF | p-value | Odds ratio | 95%CI | ||
| ALOX5AP | ||||||||||||
| SG13S25 (G/A) | 5'UTR | 138 | 35 | 2 | 0.11 | 491 | 100 | 5 | 0.09 | 0.556 | 0.87 | 0.55-1.37 |
| SG13S114 (T/A) | Intron 1 | 92 | 63 | 20 | 0.29 | 248 | 282 | 58 | 0.34 | 0.198 | 1.22 | 0.90-1.65 |
| rs3803277 (C/A) | Intron 2 | 54 | 80 | 42 | 0.47 | 184 | 303 | 103 | 0.43 | 0.318 | 0.87 | 0.65-1.15 |
| SG13S89 (G/A) | Intron 3 | 162 | 13 | 0 | 0.04 | 551 | 45 | 1 | 0.04 | 0.771 | 0.90 | 0.43-1.88 |
| rs4468448 (C/T) | Intron 4 | 100 | 65 | 11 | 0.25 | 333 | 226 | 34 | 0.25 | 0.807 | 1.04 | 0.76-1.45 |
| SG13S32 (C/A) | Intron 4 | 42 | 88 | 43 | 0.49 | 162 | 302 | 130 | 0.47 | 0.351 | 0.87 | 0.66-1.16 |
| SG13S41 (A/G) | Intron 4 | 149 | 21 | 0 | 0.06 | 524 | 62 | 6 | 0.06 | 0.542 | 0.84 | 0.47-1.48 |
| SG13S35 (G/A) | 3'UTR | 146 | 26 | 0 | 0.06 | 479 | 97 | 3 | 0.09 | 0.970 | 1.01 | 0.60-1.71 |
| LTA4H | ||||||||||||
| rs1978331 (T/C) | Intron 11 | 66 | 81 | 27 | 0.39 | 223 | 257 | 109 | 0.40 | 0.419 | 0.89 | 0.68-1.18 |
| rs17677715 (T/C) | Intron 6 | 115 | 50 | 6 | 0.18 | 372 | 188 | 26 | 0.20 | 0.899 | 1.02 | 0.72-1.46 |
| rs2660899 (G/T) | 5'UTR | 130 | 45 | 1 | 0.13 | 418 | 158 | 16 | 0.16 | 0.113 | 1.39 | 0.93-2.08 |
| rs2540482 (T/C) | 5'UTR | 107 | 58 | 8 | 0.21 | 358 | 195 | 34 | 0.23 | 0.473 | 1.13 | 0.81-1.58 |
| rs2660845 (A/G) | 5'UTR | 92 | 71 | 12 | 0.26 | 328 | 224 | 40 | 0.26 | 0.483 | 0.89 | 0.65-1.22 |
| rs2540475 (C/T) | 5'UTR | 108 | 55 | 5 | 0.19 | 358 | 186 | 27 | 0.21 | 0.770 | 0.95 | 0.67-1.35 |
| LTB4R2 | ||||||||||||
| rs2332320 (T/C) | 5'UTR | 130 | 34 | 5 | 0.13 | 440 | 124 | 13 | 0.13 | 0.977 | 1.01 | 0.67-1.52 |
| rs11158635 (G/T) | 5'UTR | 100 | 57 | 9 | 0.23 | 367 | 193 | 26 | 0.21 | 0.165 | 0.78 | 0.55-1.11 |
| rs2516564 (C/T) | 5'UTR | 104 | 59 | 9 | 0.22 | 372 | 193 | 25 | 0.21 | 0.169 | 0.79 | 0.56-1.11 |
| LTB4R1 | ||||||||||||
| rs2224122 (C/G) | 5'UTR | 102 | 55 | 9 | 0.22 | 363 | 190 | 28 | 0.21 | 0.232 | 0.81 | 0.57-1.15 |
| rs1046587 (G/A) | 3'UTR | 43 | 94 | 36 | 0.48 | 155 | 298 | 128 | 0.48 | 0.566 | 1.09 | 0.82-1.45 |
| rs3181384 (C/T) | 3'UTR | 100 | 58 | 10 | 0.20 | 363 | 191 | 28 | 0.21 | 0.111 | 0.76 | 0.54-1.07 |
Logistic regression was used to compare genotype frequencies between smoking controls (n = 176) and total COPD cases (n = 599) using the additive model with the covariates age, gender and pack-years. OR, odds ratio; 95% CI, 95% confidence interval. 0, 1 and 2 represent the number of major homozygote, heterozygote and minor homozygote genotype frequencies.