Table 3.
ALOX5AP, LTA4H and LTB4R SNPs and severe COPD (defined by GOLD stage 3 and 4) in smokers.
| SNP | Location | Controls (n = 176) | GOLD 3 and 4 (n = 389) | Additive | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 0 | 1 | 2 | MAF | 0 | 1 | 2 | MAF | p-value | Odds ratio | 95%CI | ||
| ALOX5AP | ||||||||||||
| SG13S25 (G/A) | 5'UTR | 138 | 35 | 2 | 0.11 | 325 | 60 | 2 | 0.09 | 0.231 | 0.72 | 0.42-1.23 |
| SG13S114 (T/A) | Intron 1 | 92 | 63 | 20 | 0.29 | 164 | 180 | 36 | 0.33 | 0.282 | 1.21 | 0.86-1.70 |
| rs3803277 (C/A) | Intron 2 | 54 | 80 | 42 | 0.47 | 122 | 203 | 58 | 0.42 | 0.045 | 0.72 | 0.52-0.99 |
| SG13S89 (G/A) | Intron 3 | 162 | 13 | 0 | 0.04 | 356 | 32 | 0 | 0.04 | 0.701 | 0.85 | 0.36-1.99 |
| rs4468448 (C/T) | Intron 4 | 100 | 65 | 11 | 0.25 | 221 | 146 | 18 | 0.24 | 0.882 | 0.97 | 0.67-1.41 |
| SG13S32 (C/A) | Intron 4 | 42 | 88 | 43 | 0.49 | 110 | 199 | 78 | 0.46 | 0.195 | 0.81 | 0.58-1.12 |
| SG13S41 (A/G) | Intron 4 | 149 | 21 | 0 | 0.06 | 343 | 38 | 4 | 0.06 | 0.293 | 0.71 | 0.37-1.35 |
| SG13S35 (G/A) | 3'UTR | 146 | 26 | 0 | 0.06 | 312 | 61 | 2 | 0.09 | 0.677 | 0.88 | 0.49-1.59 |
| LTA4H | ||||||||||||
| rs1978331 (T/C) | Intron 11 | 66 | 81 | 27 | 0.39 | 153 | 165 | 62 | 0.38 | 0.090 | 0.76 | 0.56-1.04 |
| rs17677715 (T/C) | Intron 6 | 115 | 50 | 6 | 0.18 | 241 | 124 | 15 | 0.21 | 0.808 | 1.05 | 0.71-1.56 |
| rs2660899 (G/T) | 5'UTR | 130 | 45 | 1 | 0.13 | 264 | 109 | 10 | 0.17 | 0.114 | 1.44 | 0.92-2.26 |
| rs2540482 (T/C) | 5'UTR | 107 | 58 | 8 | 0.21 | 231 | 129 | 19 | 0.22 | 0.677 | 1.08 | 0.74-1.58 |
| rs2660845 (A/G) | 5'UTR | 92 | 71 | 12 | 0.26 | 209 | 154 | 22 | 0.26 | 0.452 | 0.87 | 0.61-1.25 |
| rs2540475 (C/T) | 5'UTR | 108 | 55 | 5 | 0.19 | 236 | 118 | 16 | 0.20 | 0.895 | 0.97 | 0.65-1.45 |
| LTB4R2 | ||||||||||||
| rs2332320 (T/C) | 5'UTR | 130 | 34 | 5 | 0.13 | 287 | 81 | 8 | 0.13 | 0.523 | 1.17 | 0.73-1.86 |
| rs11158635 (G/T) | 5'UTR | 100 | 57 | 9 | 0.23 | 235 | 131 | 16 | 0.21 | 0.195 | 0.77 | 0.52-1.15 |
| rs2516564 (C/T) | 5'UTR | 104 | 59 | 9 | 0.22 | 238 | 130 | 15 | 0.21 | 0.195 | 0.77 | 0.52-1.14 |
| LTB4R1 | ||||||||||||
| rs2224122 (C/G) | 5'UTR | 102 | 55 | 9 | 0.22 | 228 | 130 | 18 | 0.22 | 0.365 | 0.83 | 0.56-1.23 |
| rs1046587 (G/A) | 3'UTR | 43 | 94 | 36 | 0.48 | 95 | 195 | 83 | 0.48 | 0.857 | 1.03 | 0.75-1.42 |
| rs3181384 (C/T) | 3'UTR | 100 | 58 | 10 | 0.20 | 230 | 131 | 18 | 0.22 | 0.183 | 0.77 | 0.52-1.13 |
Logistic regression was used to compare genotype frequencies between smoking controls (n = 176) and GOLD stage 3/4 cases (n = 389) using the additive model with the covariates age, gender and pack-years. OR, odds ratio; 95% CI, 95% confidence interval. 0, 1 and 2 represent the number of major homozygote, heterozygote and minor homozygote genotype frequencies. Black bold indicated (p = ≤ 0.05).