Figure 2.

Proposed mechanisms of TTR inhibition of Ab toxicity. TTR inhibition of Aβ aggregation (fibril formation) was reported by many groups [12,158,169,203-205] and current evidence suggested that the binding is mediated by association of monomeric TTR to Aβ. It is also possible that TTR facilitates Aβ degradation directly [208] or indirectly, transports of Aβ from CNS into serum (plasma sink hypothesis) [12,202]. TTR may also inhibit Aβ production by inhibition of γ-secretase cleavage [169].