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. 2012 Jan 27;7(1):e29925. doi: 10.1371/journal.pone.0029925

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Blatt et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Female NMRI-Foxn1^nu mice were inoculated with HMC-1.2 cells and were randomized into a treatment group (drug gavaging) and a control group. A: The treatment group (7 mice) received 40 mg/kg NVP-BEZ235 dissolved in NMP and PEG300 per os every day, and the control group (6 mice) received NMP and PEG300 alone for 22 days. B: The treatment group (5 mice) received 5 mg/kg RAD001 dissolved in distilled water per os, and the control group (5 mice) received sodium chloride per os for 19 days. Tumor size is shown in the vertical axis and is expressed in mm³. Results represent the mean±S.D. in each group. Asterisk (*) indicates p<0.05 compared to the control group.