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Immunohistochemical staining of SOX2 in normal colonic mucosa. Normal colonic mucosa with absent SOX2 expression (A, 200-fold magnification). Few cases (4%) reveal a positive SOX2 expression within the stem-cell niche of the colonic crypt (B, 630-fold). Also adjacent to positive tumour cell infiltrates no SOX2 expression could be detected in the normal colonic mucosa in the majority of cases (C, 200-fold).
