Table 1.

Clinico-pathological variables and correlations with SOX2 and β-catenin protein expression in the matched case-control collection of 114 CC patients. OR = odds ratio, CI = 95% confidence interval, Percent-values are given in parentheses.

Characteristic	Total (%)	SOX-2		OR (CI)	p	β-catenin (cytoplasmic)		OR (CI)	p	β-catenin (nuclear)		OR (CI)	p
		high	low			high	low			high	low
All patients	114 (100)	24 (21.1)	90 (78.9)			104 (91.2)	10 (8.8)			38 (33.3)	76 (66.7)
Age (median. 66.5) years
≤ 66	57 (50)	11 (9.6)	46 (40.4)	1.2	0.646	56 (49.1)	1 (0.9)	0.1	0.008	22 (19.3)	35 (30.7)	0.6	0.23
≥67	57 (50)	13 (11.4)	44 (38.6)	(0.5-3.0)		48 (42.1)	9 (7.9)	(0.01-0.8)		16 (14.0)	41 (36.0)	(0.3-1.4)
Gender
Male	58 (50.9)	15 (13.2)	43 (37.7)	1.8	0.20	54 (47.4)	4 (3.5)	1.6	0.471	22 (19.3)	36 (31.6)	1.5	0.29
Female	56 (49.1)	9 (7.9)	47 (41.2)	(0.7-4.6)		50 (43.9)	6 (5.3)	(0.4-6.1)		16 (14.0)	40 (35.1)	(0.7-3.4)
Tumor size (UICC)
T1	2 (1.8)	0 (0)	2 (1.8)	-	0.280	2 (1.8)	0 (0)	-	0.662	1 (0.9)	1 (0.9)	-	0.607
T2	10 (8.8)	0 (0)	10 (8.8)			10 (8.8)	0 (0)			2 (1.8)	8 (7.0)
T3	86 (75.4)	21 (18.4)	65 (57.0)			77 (67.5)	9 (7.9)			31 (27.2)	55 (48.2)
T4	16 (14)	3 (2.6)	13 (11.4)			15 (13.2)	1 (0.9)			4 (3.5)	12 (10.5)
Nodal status
N0	52 (45.6)	5 (4.4)	47 (41.2)	4.2	0.006	49 (43.0)	3 (2.6)	0.5	0.299	15 (13.2)	37 (32.5)	1.5	0.35
N+	62 (54.4)	19 (16.7)	43 (37.7)	(1.4 - 12.1)		55 (48.2)	7 (6.1)	(0.1-2.0)		23 (20.2)	39 (34.2)	(0.7-3.2)
Metastasis (liver)
M0	57 (50)	7 (6.1)	50 (43.9)	3.0	0.022	52 (45.6)	5 (4.4)	1.0	1.0	11 (9.6)	46 (40.4)	3.8	0.001
M1	57 (50)	17 (14.9)	40 (35.1)	(1.1-3.0)		52 (45.6)	5 (4.4)	(0.3-3.7)		27 (23.7)	30 (26.3)	(1.6-8.7)
Tumor grade (WHO)
G2	44 (38.6)	7 (6.1)	37 (32.5)	-	0.043	43 (37.7)	1 (0.9)	-	0.265	16 (14.0)	28 (24.6)	-	0.567
G3	66 (57.9)	15 (13.2)	51 (44.7)			58 (50.9)	8 (7.0)			21 (18.4)	45 (39.5)
G4	4 (3.5)	2 (1.8)	2 (1.8)			3 (2.6)	1 (0.9)			1 (0.9)	3 (2.6)