Table 4.
Variables | EQ-5D (n=368) (Model R2 = 0.33) |
QWB (n=369) (Model R2 = 0.28) |
VAS (n=362) (Model R2 = 0.17) |
QOL-AD (n=367) (Model R2 = 0.42) |
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β | P | R2* | β | P | R2* | β | P | R2* | β | P | R2* | |
Age | −0.011 | 0.007 | 0.01 | −0.005 | 0.299 | 0.00 | −0.001 | 0.923 | 0.00 | −0.220 | 0.173 | 0.00 |
Sex (Male) | 0.050 | < 0.0001 | 0.02 | −0.018 | 0.275 | 0.01 | 0.001 | 0.944 | 0.00 | 1.033 | 0.037 | 0.00 |
Education | 0.468 | 0.00 | 0.355 | 0.00 | 0.243 | 0.01 | 0.161 | 0.01 | ||||
Marital Status | 0.040 | 0.013 | 0.00 | 0.018 | 0.363 | 0.00 | 0.022 | 0.278 | 0.00 | 0.762 | 0.221 | 0.00 |
First Language | 0.001 | 0.942 | 0.00 | −0.023 | 0.243 | 0.00 | 0.009 | 0.673 | 0.00 | 0.790 | 0.203 | 0.01 |
Charlson Score | 0.694 | 0.00 | 0.584 | 0.01 | 0.224 | 0.01 | 0.214 | 0.01 | ||||
ADAS (Cognition) | −0.003 | 0.658 | 0.00 | 0.004 | 0.645 | 0.00 | −0.021 | 0.021 | 0.01 | −0.452 | 0.100 | 0.01 |
DAD (Function) | −0.011 | 0.158 | 0.00 | −0.016 | 0.090 | 0.01 | 0.003 | 0.764 | 0.00 | 0.168 | 0.574 | 0.01 |
NPI (Behavior) | −0.012 | 0.071 | 0.01 | −0.013 | 0.118 | 0.01 | 0.004 | 0.625 | 0.00 | −0.803 | 0.002 | 0.04 |
GDS (Depression) | −0.068 | < 0.0001 | 0.25 | −0.066 | < 0.0001 | 0.17 | −0.048 | < 0.0001 | 0.10 | −2.825 | < 0.0001 | 0.28 |
Study Center | 0.382 | 0.02 | 0.006 | 0.06 | 0.107 | 0.04 | 0.002 | 0.06 |
EQ-5D = European Quality of Life-5 Dimensions; QWB = Quality of Well-Being Index; VAS = global quality of life Visual Analog Scale; QOL-AD = Quality of Life-Alzheimer’s Disease; β = β-coefficient; P = P-value; R2* = LMG R2, the average of R2 increments from adding the variable to models without the variable, across all of the possible models; Charlson score = measure of comorbidity; ADAS-Cog = Alzheimer’s Disease Assessment Scale-Cognitive sub-scale; DAD = Disability Assessment for Dementia; NPI = Neuropsychiatric Inventory; GDS = Geriatric Depression Scale.
All single parameter tests are t-tests with estimated degrees of freedom (df) ranging between 253 and 344. All multiple parameter tests are F-tests and these included: tests for education (numerator df = 2, denominator df > 300), the Charlson comorbidity score (numerator df = 2, denominator df > 300), and study center (numerator df = 9, denominator df > 300).