Table 1.

Optimised parameters from the mathematical model describing the proportion of MDTF cells expressing EYFP that also expressed EGFP

System	Number of receptors needed for viral entry k	Model error D	Efficiency of delivery vector p	Number of receptors produced for each TVA integration r	Receptor efficiency q	Relative rate at which bound viruses acquire more receptors γ
Tva950	1	0.0258	1	1.579	0.198	n/a
Tva800	1	0.106	0.25	0.921	1	n/a
Tva800	1	0.176	1*	0.925	0.300	n/a
Tva800	2	0.120	1	0.979	0.992	9.837
Tva800	3	0.165	1	0.990	1	159.3

In each case the number of receptors needed for viral entry was fixed, while other parameters were optimised to maximise the fit to the experimental data. A calculation for Tva800 with one receptor needed for viral entry was rerun, with the efficiency of the delivery vector fixed to match that obtained for Tva950. The error D gives the RMSD difference between the model and the experimental data in each case. Efficiencies are expressed as probabilities, such that an efficiency of 1 is equivalent to 100%.

*parameter fixed, not optimised