Table 2.
First degree family history of unprovoked seizure and risk for psychiatric disorders in probands with childhood onset epilepsy
| Behavioral disorder from CBCL | Uncomplicated epilepsy1 (N=213) | Complicated epilepsy2 (N=95) | ||||
|---|---|---|---|---|---|---|
| Family history of unprovoked seizure (N=24) | No family history of unprovoked seizure (N=189) | PR (95% CI) | Family history of unprovoked seizure (N=9) | No family history of unprovoked seizure (N=86) | PR (95% CI) | |
| Clinical cut off | ||||||
| Total problems | 7 (29.2%) | 20 (10.6%)p=0.018 | 2.8 (1.3–5.8) | 3 (33.3%) | 19 (22.0%)p=0.43 | 1.5 (0.6–4.1) |
| Internalizing disorders | 8 (33.3%) | 30 (15.9%)p=0.047 | 2.1 (1.09–4.0) | 2 (22.2%) | 17 (19.8%)p=1.0 | 1.2 (0.3–4.1) |
| Externalizing disorders | 5 (20.8%) | 21 (11.1%)p=0.19 | 1.9 (0.8–4.5) | 2 (22.2%) | 11 (12.8%)p=0.61 | 1.7 (0.5–6.6) |
| Anxious/Depressed | 3 (12.5%) | 12 (6.4%)p=0.39 | 2.0 (0.6–6.5) | 1 (11.1%) | 7 (8.1%)p=0.56 | 1.3 (0.2–9.9) |
| Withdrawn/Depressed | 4 (16.7%) | 9 (4.8%)p=0.044 | 3.5 (1.2–10.5) | 1 (11.1%) | 8 (9.3%)p=1.0 | 1.2 (0.2–8.5) |
| Somatic Complaints | 4 (16.7%) | 17 (9.0%)p=0.27 | 1.9 (0.7–5.1) | 0 (0%) | 7 (8.1%) p=1.0 | NA |
| Thought Problems | 2 (8.3%) | 11 (5.8%)p=0.64 | 1.4 (0.3–6.1) | 1 (11.1%) | 9 (10.5%) p=1.0 | 1.1 (0.2–7.5) |
| Attention Problems | 4 (16.7%) | 12 (6.4%)p=0.089 | 2.6 (0.9–7.5) | 0 (0%) | 17 (19.8%)p=0.35 | NA |
| Intrusive Problems | 2 (8.3%) | 13 (6.9%)p=0.68 | 1.2 (0.3–5.1) | 2 (22.2%) | 13 (15.1%) p=0.63 | 1.4 (0.4–5.5) |
| Aggressive Behavior | 4 (16.7%) | 6 (3.2%)p=0.017 | 5.3 (1.6–17.3) | 0 (0%) | 3 (3.5%) p=1.0 | NA |
| Delinquent Behavior | 4 (16.7%) | 10 (5.3%)p=0.057 | 3.2 (1.1–9.3) | 0 (0%) | 8 (9.3%) p=1.0 | NA |
| DSM diagnoses | ||||||
| Affective Disorder | 5 (20.8%) | 14 (7.4%)p=0.046 | 2.8 (1.1–7.1) | 1 (11.1%) | 13 (15.1%) p=1.0 | 0.7 (0.1–5.0) |
| Anxiety Disorder | 5 (20.8%) | 15 (7.9%)p=0.057 | 2.6 (1.1–6.6) | 1 (11.1%) | 8 (9.3%) p=1.0 | 1.2 (0.2–8.5) |
| ADHD3 | 1 (4.2%) | 9 (4.8%)p=1.0 | 0.9 (0.1–6.6) | 0 (0%) | 5 (5.8%) p=1.0 | NA |
| Conduct Disorder | 4 (16.7%) | 7 (3.7%)p=0.024 | 4.5 (1.4–14.3) | 0(0%) | 6 (7.0%) p=1.0 | NA |
| Oppositional Defiant Disorder | 5 (20.8%) | 10 (5.3%)p=0.016 | 3.9 (1.5–10.6) | 0 (0%) | 3 (3.5%) p=1.0 | NA |
1
Uncomplicated: Subject has cognitive function consistent with IQ >80 and no identified structural brain lesion or similar condition to which the epilepsy can be attributed.;
2
Complicated: Subject has cognitive function level consistent with IQ<80 or there is a documented brain lesion or related condition to which the occurrence of epilepsy has been attributed;
3
Attention Deficit Hyperactivity Disorder;
NA - Model did not converge