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. Author manuscript; available in PMC: 2012 Aug 1.
Published in final edited form as: Nat Neurosci. 2011 Nov 27;15(2):274–283. doi: 10.1038/nn.2997

Figure 2. Behavioral characterization of MeCP2 T158A mice.

Figure 2

(a) Locomotor activity in Mecp2T158A/y mice (n = 15), Mecp2−/y mice (n = 14) and Mecp2+/y littermates (WT; n = 33) at 9 weeks of age. Bars represent mean ± SEM. * p-value < 0.01, *** < 0.001 and ## < 0.01; one-way ANOVA with Tukey’s post hoc test. (b) Motor coordination and motor learning assessed using a rotarod assay in Mecp2T158A/y mice (n = 16; F1,645 = 447.2, p-value < 0.0001; two-way ANOVA) and Mecp2−/mice (n = 14; F1,602 = 841.46, p-value < 0.0001; two-way ANOVA) and WT littermates (n = 27) at 9 weeks of age. The deficit in Mecp2−/y mice is significantly more than that observed in Mecp2T158A/y mice (F1,437 = 83.82, p-value < 0.0001; two-way ANOVA). Symbols represent mean ± SEM. (c) Anxiety-like behavior in Mecp2T158A/y mice (n = 15) and Mecp2−/y mice (n = 11) measured using elevated zero maze compared to WT littermates (n = 32) at 9 weeks of age. Bars represent mean ± SEM. * p-value < 0.05 and ** < 0.01; one-way ANOVA with Tukey’s post hoc test. (d) Learning and memory assessed using context-and cue-dependent fear conditioning in Mecp2T158A/y mice (n = 16) and WT littermates (n = 33) at 10 weeks of age. Bars represent mean ± SEM. * p-value < 0.05 and *** < 0.001; two-tailed t-test with Bonferroni correction.