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. Author manuscript; available in PMC: 2013 Feb 1.
Published in final edited form as: Free Radic Biol Med. 2011 Dec 16;52(3):705–715. doi: 10.1016/j.freeradbiomed.2011.11.027

Figure 1. Naïve mice deficient in NQO1 develop accelerated emphysematous changes.

Figure 1

Naïve age-matched C57BL/6 and NQO1 deficient mice were evaluated at 1, 2, 4 and 6 months. A, Gross lung photographs demonstrated that NQO1 deficient mice have physically larger lungs beginning at two months and continuing with age when compared to C57BL/6 lungs. B, Lung histology shows increased airspace enlargement in the NQO1 deficient mice beginning at two months of age with greater enlargement with age consistent with the development of premature emphysema. C–E, NQO1 deficient mice develop progressive airspace enlargement as measured my mean line intercept (MLI) (C), increased static compliance (D), and increased residual volume (E) when compared to C57BL/6 mice. The static compliance, residual volume and mean line intercept measurements were performed on 10 mice per group with 2 repeats. The values are presented as the mean ± SEM (*P <0.05).