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. Author manuscript; available in PMC: 2013 Feb 1.
Published in final edited form as: Free Radic Biol Med. 2011 Dec 16;52(3):705–715. doi: 10.1016/j.freeradbiomed.2011.11.027

Figure 3. NQO1 deficient mice have enhanced development of elastase-induced emphysema.

Figure 3

NQO1 deficient and C57BL/6 mice, age three weeks, were provided either standard water or water with the antioxidant, N-acetyl cysteine (NAC). At 4 weeks, these groups received either porcine pancreatic elastase (PPE) or saline by oropharyngeal aspiration and then analyzed thirteen days post exposure. A, C, D, Static lung compliance (A) and pressure volume measurements (C, D) demonstrated an increase in compliance of the elastase treated NQO1 deficient mice as compared to WT mice. These effects were reversed by pre-treatment with NAC. B, Enhanced airspace enlargement (as measured by mean line intercept) in NQO1 deficient and WT mice after elastase exposure was also reversed with NAC pretreatment. E, 8-isoprostane and protein carbonyl concentrations (measurements of oxidative stress) were quantitated from the BALF. The values in A, B and E represent the mean ± SEM of evaluations of > 10 mice with 2 repeats (*P <0.05)