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. Author manuscript; available in PMC: 2013 Feb 1.
Published in final edited form as: Free Radic Biol Med. 2011 Dec 16;52(3):705–715. doi: 10.1016/j.freeradbiomed.2011.11.027

Figure 4. NQO1 deficient mice have enhanced development of LPS-induced emphysema.

Figure 4

At three weeks of age, NQO1 deficient and C57BL/6 mice were pretreated with standard or NAC treated water and then exposed to LPS on alternating days (3 times) at four weeks of age and then allowed to recover for four weeks. A–D, Measurements of emphysematous changes: static lung compliance (A), alveolar space enlargement (MLI) (B), pressure volume measurements (C, D) from LPS/Saline ± NAC treated NQO1 deficient and C57BL/6 mice. E, Oxidative stress levels were quantitated by measuring 8-isoprostanes and protein carbonyls in the BALF. The values in A, B and E represent the mean ± SEM of evaluations of > 10 mice with 2 repeats (*P <0.05)