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. Author manuscript; available in PMC: 2012 Jan 28.
Published in final edited form as: Nat Genet. 2009 Nov 15;41(12):1335–1340. doi: 10.1038/ng.489

Figure 1.

Figure 1

Overview of genome-wide association results. (a–c) Chromosomal plots of –logP against genomic location for discovery scans in the early-onset DC-CD (a), DC-UC (b) and DC-IBD (c) cohorts. Red and blue dotted lines represent thresholds for genome-wide significant (P = 1 × 10−7) and suggestive (P = 1 × 10−6) signals, respectively. Loci on 16p11, 22q12 and 2q37 emerged from these analyses as suggestive signals and were validated in the follow-up cohorts RC1 and RC2-CD. The following signals did not replicate or show significance in the meta-analysis: 1q22 (CD), 10q25 (UC), 16q21 (UC), 18q12 (UC), 8q24 (IBD) and 15q22 (IBD). The remaining loci have been previously identified in majority adult-onset genome scans of Crohn’s disease and ulcerative colitis. Loci on 22q12 and 20q13 were identified in a previous early-onset IBD scan involving a subset of the cohort analyzed in this study1.