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. Author manuscript; available in PMC: 2012 Jan 28.
Published in final edited form as: Nat Genet. 2009 Nov 15;41(12):1335–1340. doi: 10.1038/ng.489

Figure 2.

Figure 2

Colonic and LCL mRNA expression of genes in significantly associated loci. The A allele of rs1968752 confers risk in our early-onset Crohn’s disease and IBD cohorts (OR = 1.23 (1.12–1.40)). rs1968752 lies in a block of LD containing the IL27 gene. (a) Cell lines from individuals (n = 5) with the A/A genotype at rs1968752 have over 90% decrease in IL27 gene expression as compared with those with the C/C genotype. (b) IL27 colonic expression was significantly lower in samples obtained from individuals with early-onset Crohn’s disease and ulcerative colitis cases than in normal tissue. (c,d) Expression of both SULT1A1 (c) and SULT1A2 (d) genes (also in the IL27 locus) was also significantly lower in Crohn’s disease and ulcerative colitis tissue than in normal tissue. (e,f) Expression of putative IBD gene MTMR3 at 22q12 (e) and the putative ulcerative colitis gene CAPN10 at 2q37 (f) was significantly lower in ulcerative colitis tissue than in normal tissue. All significant expression effects were found to be independent of treatment and histological inflammation score (data not shown). Error bars represent s.e.m.