Table 4.
Newly discovered effects of previously known or suggested adult IBD risk loci in early-onset IBDa
| CD (DC-CD, RC1-CD) (n = 1,925 / 7,854) |
UC (DC-UC, RC1-UC) (n = 844 / 7,854) |
IBD (DC-IBD, RC1) (n = 2,895 / 7,854) |
|||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CDkb | CDpb | UCkb | UCpb | Band | Mb | Genes | SNP | P | Z | P | Z | P | Z |
| • | 1q32.1 | 205.01 | IL10, IL19, IL20 | rs3024505 | 4.84 × 10−4 | 3.49 | 6.20 × 10−4 | 3.42 | 6.84 × 10−6 | 4.50 | |||
| • | 2q12.1 | 102.44 | IL18R1, IL18RAP | rs917997 | 6.84 × 10−5 | 3.98 | 0.17 | 1.38 | 5.98 × 10−5 | 4.01 | |||
| • | 17q12 | 29.61 | CCL11, CCL2, CCL7 | rs991804 | 2.31 × 10−4 | −3.68 | 2.78 × 10−2 | −2.20 | 6.64 × 10−5 | −3.99 | |||
| • | 17q12 | 35.29 | ORMDL3 | rs2872507 | 3.65 × 10−4 | 3.56 | 7.62 × 10−4 | 3.37 | 3.13 × 10−6 | 4.66 | |||
| • | 21q22.3 | 44.44 | ICOSLG1 | rs762421 | 3.32 × 10−7 | 5.10 | 2.54 × 10−5 | 4.21 | 3.19 × 10−10 | 6.29 | |||
Listed are 5 of 49 previously identified adult-onset IBD loci that were either (1) previously nominal adult IBD signals that are verified by our data or (2) validated adult signals previously shown to have an effect on early-onset UC (CD) and found in our study to have an effect on early-onset CD (UC).
Filled circles in the first four columns of the table specify whether the given row represents a known CD locus (CDk), putative/nominal CD locus (CDp), known UC locus (UCk) and/or putative/nominal UC locus (UCp). Loci replicating at a Bonferroni-corrected P < 0.05 (corrected for 49 hypotheses) are denoted in bold; newly discovered significant effects are denoted in bold italics.