Figure 1.

The principle for generation of monospecific antibodies. The polyclonal serum is assayed with a peptide array spanning the antigen sequence to identify the epitopes of the antibodies (A). The epitope corresponding peptides as well as the recombinant antigen are coupled to columns which are mounted in a serial manner after a protein tag specific column onto which the polyclonal serum is applied (B). Bound antibodies are eluted in parallel to create monospecific antibodies which are evaluated in different paired antibody applications (C).