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Circular permutation of a 4E10 epitope-scaffold. The original termini of the epitope-scaffold are labeled in the left panel. The cutting point to generate the novel termini and the designed linker to join the original termini are schematically represented in the middle panel. The final permuted epitope-scaffold is shown in the right panel. The spatial proximity of the his tag (H) to the 4E10 antibody is also illustrated on the left panel.
