Fig. 1.

Dietary supplementation with coenzyme Q10 reduced brain oxidative stress. Tg19959 mice were fed for three months with control chow or chow supplemented with 0.4% CoQ10 (800 mg/kg/day). A) Oxidative stress was assessed by Western blotting for protein carbonyls in 6% SDS brain homogenates. B) Densitometry. Samples were run in pairs, with one CoQ10-fed animal and one control-fed animal in each pair. In each pair, the total carbonyl densities from both the CoQ10-fed animal and the control-fed animal were divided by that of the control-fed animal. The graph shows the mean ± SEM for these ratios. *p = 0.0017, two-tailed t-test. n = 11 pairs were run.