Table 4. Classification of Lewy Body Disease.

Results form the tiered approach to assessment of LBD in Table 1 should be as described here. Neocortical (diffuse) LBD is considered adequate explanation of dementia (shaded gray). It is important to note this classification is focused on the clinical context of cognitive impairment or dementia. LBD also occurs early in olfactory bulb, and even can occur outside of the brain.

None	No LBs or related changes in IHC for α-synuclein
Brainstem-predominant	LBs in medulla, pons, or midbrain
Limbic (Transitional)	LBs in cingulate or entorhinal cortices, usually with brainstem involvement
Neocortical (Diffuse)	LBs in frontal, temporal, or parietal cortices usually with involvement of brainstem and limbic sites, which may include amygdala
Amygdala-predominant	LBs in amygdala with paucity of LBs in the above regions