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. Author manuscript; available in PMC: 2012 Jan 28.
Published in final edited form as: DNA Repair (Amst). 2008 Nov 20;8(1):126–136. doi: 10.1016/j.dnarep.2008.09.004

Fig. 4.

Fig. 4

Striatal cells from aged mice exhibit higher levels of 8-OHG and 8-OHdG and delayed repair kinetics. 5- and 24-month-old C57BL/6 mice were injected with 100 mg/kg of 3-NPA and brain sections were obtained at 0 (control), 6, 12, 24, and 48 h after treatment. The number of 8-OHG and 8-OHdG positive cells were determined by immunocytochemistry. Panel A represents striatal sections from 5- and 24-month-old mice at 0 (untreated/controls) and 24 h after 3-NPA. Panel B represents the number of 8-OHG and 8-OHdG positive cells at 0, 6, 12, 24, 48 h after 3-NPA; n = 2 mice per age and treatment groups.